Decentralized Research Funding Allocation for Neglected Diseases

C5/10April 26, 2026
WhatA platform that enables quadratic funding or prediction-market-based allocation of research grants, bypassing traditional gatekeeper-controlled peer review panels.
SignalCommenters are frustrated that a small number of gatekeepers control research direction, that funding is driven by marketing rather than disease burden metrics, and that diseases like ME/CFS receive 1/40th the funding of Alzheimer's despite comparable patient populations.
Why NowCrypto-native quadratic funding mechanisms (Gitcoin) have proven viable, NIH budget cuts are creating a vacuum for alternative funding, and public trust in traditional grant allocation is at a low point after fraud scandals.
MarketPhilanthropic health research funding (~$30B/year globally) is the TAM; key gap is that existing platforms like Experiment.com are tiny and lack sophisticated allocation mechanisms.
MoatNetwork effects from researcher reputation scores and donor communities, plus proprietary outcome-tracking data that proves which funding approaches yield results.
Why has there been so little progress on Alzheimer's disease? View discussion ↗ · Article ↗ · 418 pts · April 26, 2026

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